Services Methods Development ANALYSIS & APPLICATIONS Analysis of small organic pharmaceuticals (drug substance) Formulation polymer characterization Polymer pharmaceuticals characterization Biopharmaceutical products analysis Protein aggregation studies  Complex formulation analysis (drug product) Particle size distribution measurement of formulations Particle stability assesment PROCESS ANALYTICAL CHEMISTRY (PAC) Method development for PAC POLYMER SOLUBILITY STUDIES Polymer solubility measurements Polymer solubility mapping DRUG SUBSTANCE EXTRACTION  (METHOD DEVELOPMENT AND OPTIMIZATION)  Drug substance solubility measurement Drug substance extraction from complex tablet or capsule formulations Drug substance recovery optimization Drug substance and polymer solubility matching PARTICLE SIZE DISTRIBUTION AND PARTICLE COUNTING Particle size determination Particle size distribution Particle size changes during processes PROTEIN ADSORPTION STUDIES Protein adsorption isotherm determination Protein adsorption to surfaces Protein conformational changes at solid interfaces   Polymer Characterization and Polymer Derivatization QUANTITATIVE SOLUBILITY MAPPING (QSM) The solubility of polymers are measured by various analytical methods under systematically selected solvent conditions.  The measured polymer solubility values are displayed in a solubility map.  Since the solubility data are quantitative, a Quantitative Solubility Map can be constructed.  The solubility values of drug substances can be also measured and displayed on the QSM.  The generated QSM can be an irreplacable tool for formulation, extraction optimization and analytical method development. QSM allows the experimental determination of solubility parameters (Hildebrand and Hansen). SUBJECTS Polymers and polymer derivatives Polyethylene Oxides (PEO)  Polyethylene Glycols (PEG) Polyvinyl Alcohols (PVA) Hydroxyl propyl cellulose (HPC) Hydroxyl propyl methyl cellulose (HPMC) Polyvinyl alcohol (PVA) Polyvinyl pyrrolidone (PVP) Opadry characterization Proteins and Polypeptides TECHNIQUES Chromatography GPC, SEC, RPLC, Ion Exchange Chromatography (IEX) Dynamic Light Scattering  Viscosity High Performance Capillary Electrophoresis (HPCE), SDS and Native Gel Electrophoresis Protein Separation, Purification and Analysis PROTEIN SOLUBILITY MAPPING pH and ionic strength relationship SEPARATION Reversed phase separation (RPLC) Size exclusion chromatography (SEC, GPC)  Identification of on column conformational changes Optimization of native protein recovery PURIFICATION Reversed phase (RPLC) Size exclusion (SEC) Ion exchange (IEX) Hydrophobic Interaction Chromatography (HIC) ANALYSIS Purity determination (HPLC, SDS-PAGE, CGE) Protein aggregation studies (HPLC, LIGHT SCATTERING, PARTICLE SIZING)  Capillary Electrophoresis (CE) Capillary Gel Electrophoresis (CGE) Capillary Isoelectric Focussing (CIEF) HPLC and Capillary Electrophoresis based analytical method development BIOTECHNOLOGY In collaboration with our partners we can provide full biotechnology service, Mammalian protein synthesis Protein characterization Protein purification development Protein formulation development Protein analytical method development